OBSERVATIONAL THERAPEUTICS: SCOPE, CHALLENGES, AND ORGANIZATION

Observational therapeutics: Scope, challenges, and organization

The importance of Observational Therapeutics in the progress of medicine has been neglected in the current era of the hierarchal position imparted to Randomized Controlled Trials (RCTs) for new drug discovery and practice of evidence-based medicine.There is a need to reflect on the reason for many new drugs being withdrawn Lip Liner during post mar

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Clinical undernutrition in 2014: pathogenesis, early diagnosis and consequences; undernutrition and trophopathy

The last ten years have allowed me to mature some concepts and criteria in relation to malnutrition in the clinical practice.A lot of us have devoted all our efforts in an attempt to take it under control.The results, however, have shown to be insufficient in the clinical practice, because Hospital Undernutrition still persists in our hospitals and

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Therapeutic Antibody-Like Immunoconjugates against Tissue Factor with the Potential to Treat Angiogenesis-Dependent as Well as Macrophage-Associated Human Diseases

Accumulating evidence suggests that tissue factor (TF) is selectively expressed in pathological angiogenesis-dependent as well as macrophage-associated human diseases.Pathological angiogenesis, the formation of neovasculature, is involved in many clinically significant human diseases, notably cancer, age-related macular degeneration (AMD), endometr

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